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EMF Studies

25 January 2016

Effects of Microwave Radiation on Brain Energy Metabolism and Related Mechanisms

Effects of microwave radiation on brain energy metabolism and related mechanisms
Mil Med Res. 2015; 2: 4.
Published online 2015 Feb 17. doi: 10.1186/s40779-015-0033-6

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With the rapid development of electronic technologies, anxiety regarding the potential health hazards induced by microwave radiation (MW) has been growing in recent years. The brain is one of the most sensitive target organs for microwave radiation, where mitochondrial injury occurs earlier and more severely than in other organs. Energy metabolism disorders do play an important role during the process of microwave radiation-induced brain damage. In this paper, we will review the biological effects of microwave radiation, the features of brain energy supply and consumption and the effects of microwave radiation on mitochondrial energy metabolism and potential related mechanisms.



To date, the damaging effects of MW radiation on mitochondrial structure and function have been recognized, and studies at the cellular and molecular level on the related mechanisms have also made advances, enabling a number of potential molecular targets for the prevention and treatment of MW radiation to be proposed.

The following issues are present in this sphere of research: (a) MW radiation-induced disturbance of brain energy metabolism involves numerous parameters, such as the dose, time and frequency, which need to be explored further; (b) the biological effects of MW radiation are widespread, involving varieties of signaling pathways, and the present review is confined to investigating single signaling pathways and unable to analyze the effects of cross-talk between the various signaling pathways; (c) there are no specific markers for evaluating MW radiation damage effects and no effective molecular targets for the prevention and treatment of their injuries; (d) the after effects of MW radiation-induced mitochondrial damage are still unclear, and its correlation with mitochondria-related neurodegenerative diseases, such as Alzheimer’s disease, requires further study. The lack of identical standards among different laboratories creates a barrier for further development and exchange of information.

Taken together, this review on the effects of MW radiation on brain energy metabolism and the associated regulation mechanisms, molecular markers, drug targets and prevention measures shows the need for continued research efforts in this area.


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