Root Cause in the Dramatic Rise of Chronic Disease (Draft Paper on Peroxynitrite and Health)

Root Cause in the Dramatic Rise of Chronic Disease

(draft paper on peroxynitrite and health), posted on this blog on 26 May 2016

Link to draft paper.

(UPDATE  1 June 2016):  
See also Link to Dr. Martin Pall's protocol for treating oxidative stress illnesses.

Richard Lear, the author of the draft paper, says:

"It should be noted that this paper remains unfinished and is intended to stimulate awareness and research on peroxynitrite; the biological chaos it imposes; and the clear connection to a whole host of chronic diseases and conditions .

I hope to identify a PhD scientist or two, who may join this paper and help bring credibility and increased access to the topic. If you have any ideas to this end, I’d greatly appreciate it. "

Richard Lear 

richardlear@alumni.brown.edu

Introduction to the paper by Cecelia Doucette

Dear EMF Stakeholders,

I have had the privilege of reviewing the attached document, Root Cause in the Dramatic Rise of Chronic Disease. The author, Rich Lear, specializes in pattern recognition. He has mined our U.S. government databases and identified 40 diseases that have more than doubled since 1990, some exponentially. As many have already concluded they cannot be primarily genetic since we have not gone cradle-to-grave with even one generation in that time span so the cause must be environmental toxins.




A primary culprit looks to be peroxynitrite, which many of you will recognize from recent work by Dr. Martin Pall and earlier work by Dr. Pal Pacher and his colleagues. Mr. Lear is also discussing the peroxynitrite link with MIT's Dr. Stephanie Seneff (introduced at 18:35) who is studying the effects of glyphosate and other food chemicals on chronic illness.

Mr. Lear is looking for a Ph.D. or two who might collaborate to move this information forward for publication and into mainstream. Please contact him directly if you can help, his email address is given in the attached.

For those advocating for safe technology, the $2.5 trillion annual cost to society Mr. Lear identifies may be useful information to share with lawmakers looking for cost saves, and public health officials. The statistics on the rise of Autism, youth bi-polar, social/emotional issues, behavioral problems, ADD/ADHD, sleep disorders, diabetes, and others may be good speaking points with school administrators. And then there are other diseases escalating like fibromyalgia, chronic fatigue syndrome, food allergies and more that will be good public discussion.

I hope you will find Mr. Lear's work enlightening, and that it might help us to raise awareness of the damage caused by EMFs and other environmental toxins.

Thanks, as ever, for your time and consideration.

Cece Doucette
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The Root Cause in the Dramatic Rise of Chronic Disease (draft paper)

Full draft text:  Root Cause in the Dramatic Rise of Chronic Disease

NOTE to Readers: I am seeking one or two scientists to take the following research and paper forward. There are really two papers here. One is a paper that strengthens the scientific connection between peroxynitrite and at least forty fast-growing chronic diseases. The second paper is a translation of the science that can be offered to the American people, who remain unaware of the root cause of the dramatic increase of chronic disease and conditions in the US. More than 170 million Americans are currently suffering from diseases and conditions that can be vastly improved or even reversed by reducing levels of peroxynitrite through moderate changes in lifestyle, the immediate environment and diet plus nonprescription supplementation. While scientists recognize the pivotal role of peroxynitrite in disease, few policy makers and physicians are aware of the opportunity they have to heal a nation suffering from chronic diseases. The annual cost of just forty fast-growing diseases is more than $2.5 trillion. With increased awareness and action this cost to society can be reduced to a fraction by simply implementing the knowledge we already have.  

Richard Lear 

richardlear@alumni.brown.edu 

Growth of Chronic Disease 

There has been unprecedented growth in a new class of chronic diseases in the US since 1990. Four categories of disease have virtually exploded: autoimmune, neurological, metabolic and inflammatory. Meanwhile, there has been a similar uptick in reproductive conditions like infertility and a half dozen psychiatric disorders. 

While the major health threats of the 20th century: cardiovascular disease, infectious disease and cancer, are barely growing, at least forty chronic diseases and disorders have more than doubled in the past generation. Many of these new age diseases weren’t even on our radar until the 1980’s. 

In a single generation, there has been a dramatic acceleration * in the prevalence of diseases and disorders like autism (2094%), Alzheimer’s (299%), COPD (148%), diabetes (305%), sleep apnea (430%), celiac disease (1111%), ADHD (819%), asthma (142%), depression (280%), bipolar disease in youth (10833%), osteoarthritis (449%), lupus (787%), inflammatory bowel disease (IBD – 120%), chronic fatigue syndrome (11027%), fibromyalgia (7727%), multiple sclerosis (117%) and hypothyroidism (702%). 

The values for these increases were derived from scientific literature; that they are overprecise is a given. These generational increases in prevalence are offered to convey a clearer picture of the spectacular increase in chronic disease. 

Diseases of Civilization 

These are the so-called diseases of civilization. None are associated with an identifiable pathogen. Root causes remain elusive. Since genetics of humans have remained substantially unchanged over time, most believe these diseases are linked to our diet, lifestyle and/or environment. 

The impact from germless disease in America is staggering. In a population of 322 million, there are now more than 700 million instances of the forty fast-growing chronic diseases and medical conditions tracked in this article (See Table 1). Americans are suffering from an average of 2.1 chronic diseases per person across this select group. Annual economic impact, which includes medical costs, lost income and medical research is estimated to be just over $2.5 trillion (see Table 1). 

The Smoking Gun 

While controversy remains over possible external causes, one internal biological trigger may already be known. A single molecule produced by the body called peroxynitrite is associated with much of this sudden explosion of disease. In January 2007 three leading scientists, funded by the National Institutes of Health (NIH), published, “Nitric Oxide and Peroxynitrite in Health and Disease,” 1 This paper details the massive destructive capabilities of peroxynitrite (ONOO¯). 

The lead author, Dr. Pal Pacher, who has authored 260 peer-reviewed publications, is among the top 50 most-cited researchers in the pharmacology and toxicology fields worldwide. He is joined by Ph.D.’s Joseph Beckman and Lucas Liaudet. Beckman is Principal Investigator and Burgess and Elizabeth Jamieson Chair in Healthspan Research, Linus Pauling Institute at Oregon State University. Lucas Liaudet, who is affiliated with University Hospital at Lausanne, has published more than 200 peer-reviewed papers with over 10,000 citations. 

Together, this team details the cytotoxic effects, tissue damage and biochemical disruption of peroxynitrite and then systematically connects the molecule to more than 60 chronic diseases. Among them: neurodegenerative disorders, heart disease, vascular disease, accelerated aging, hypertension, inflammatory disease, cancer, stroke, arthritis, IBS, kidney disease, liver disease, Alzheimer’s, MS and diabetes. 

Until now many in the scientific community has been reticent to propose a unifying factor that explains the dramatic rise of so many seemingly unrelated diseases. Yet, there is growing evidence that peroxynitrite may just be that elusive factor. I recently asked Dr. Pacher, if it would be hyperbole to call peroxynitrite a “smoking gun” for chronic disease. Without hesitation he replied, “Absolutely not!” 

Though peroxynitrite is not strictly a free radical, it acts as both an oxidative and nitrative agent, causing extensive cellular damage, while disrupting at least 97 critical biological processes (see appendix). This molecule is set loose by the combination of two free radicals, one of which is nitric oxide (NO). Among the most studied molecules in the body, nitric oxide is known to be critical to almost every cellular function. When found in close proximity, it combines with superoxide (O2) to create peroxynitrite (ONOO¯). In turn, peroxynitrite catapults our sensitive biochemistry into unimaginable chaos. 

Left unchecked, peroxynitrite single-handedly creates high levels of oxidative stress (OS), nitrative stress (NS), mitochondrial dysfunction (MD) and autonomic dysfunction (AD) while triggering cytokine storms, which then lead to chronic systemic inflammation (CI). By stealing electrons from important biological actors like lipids (essential fats), proteins and enzymes, peroxynitrite wreaks havoc on cellular integrity and function, upends ATP (energy) production, interferes with ion messaging and disrupts key neurotransmitters. Meanwhile the prolific anion recklessly damages DNA, which leads to downstream genotoxic effects and cultivates an ideal biological environment for disease. 

The Chronic Disease State

Continue reading:

Root Cause in the Dramatic Rise of Chronic Disease