Environmental Health Trust, Nov 2, 2020
New review study finds that heavier cell phone use increases tumor risk
Press Release from Dr. Joel Moskowitz. More at Electromagnetic Radiation Safety
November 2, 2020
[Abstract and link to open-access study.]
(Berkeley, CA, November 2, 2020) Today, the International Journal of Environmental Research and Public Health published a systematic review and meta-analysis of the case-control research on cell phone use and tumor risk.
This study updates our original meta-analysis (i.e., quantitative research review) published in the Journal of Clinical Oncology in 2009. The new review examined twice as many studies as our original paper.
“In sum, the updated comprehensive meta-analysis of case-control studies found significant evidence linking cellular phone use to increased tumor risk, especially among cell phone users with cumulative cell phone use of 1000 or more hours in their lifetime (which corresponds to about 17 min per day over 10 years), and especially among studies that employed high quality methods.”
The abstract and excerpts from this open access paper appear below:
Yoon-Jung Choi+, Joel M. Moskowitz+, Seung-Kwon Myung*, Yi-Ryoung Lee, Yun-Chul Hong*. Cellular Phone Use and Risk of Tumors: Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health. 2020, 17(21), 8079; https://doi.org/10.3390/ijerph17218079 (registering DOI).
We investigated whether cellular phone use was associated with increased risk of tumors using a meta-analysis of case-control studies. PubMed and EMBASE were searched from inception to July 2018. The primary outcome was the risk of tumors by cellular phone use, which was measured by pooling each odds ratio (OR) and its 95% confidence interval (CI). In a meta-analysis of 46 case-control studies, compared with never or rarely having used a cellular phone, regular use was not associated with tumor risk in the random-effects meta-analysis. However, in the subgroup meta-analysis by research group, there was a statistically significant positive association (harmful effect) in the Hardell et al. studies (OR, 1.15—95% CI, 1.00 to 1.33— n = 10), a statistically significant negative association (beneficial effect) in the INTERPHONE-related studies (case-control studies from 13 countries coordinated by the International Agency for Research on Cancer (IARC); (OR, 0.81—95% CI, 0.75 to 0.89—n = 9), and no statistically significant association in other research groups’ studies. Further, cellular phone use with cumulative call time more than 1000 hours statistically significantly increased the risk of tumors. This comprehensive meta-analysis of case-control studies found evidence that linked cellular phone use to increased tumor risk.
+Contributed equally to this study as the first author. *Correspondence: firstname.lastname@example.org (S.-K.M.); email@example.com (Y.-C.H.)
3.5. Exposure–Response Relationship Between Use of Cellular Phones and Risk of Tumors
Table 3 shows an exposure-response relationship between cellular phone use and tumor risk. In the subgroup meta-analysis by time since first use or latency, overall the risk of tumors by cellular phone use non-significantly increased from an OR of 0.97 to 1.29 as latency increased from less than 5 years to 10 or more years. This finding was observed in each subgroup meta-analysis by research group. Especially, statistically significant increased tumor risk was observed for latency of 10 or more years in the Hardell studies (OR, 1.62; 1.03 to 2.57; n = 5; I2 = 39.9%). Similarly, the use of cellular phones non-significantly increased the risk of tumors as the cumulative or lifetime use in years and the cumulative number of calls increased in all studies and in each study group. Remarkably, in the subgroup meta-analysis of all studies by cumulative call time, cellular phone use greater than 1000 hours statistically significantly increased the risk of tumors (OR, 1.60; 1.12 to 2.30; n = 8; I2 = 74.5%). Interestingly, the use of cellular phones overall and in the Hardell studies (OR, 3.65; 1.69 to 7.85; n = 2, especially in the Hardell studies) non significantly increased the risk of tumors with cumulative call time of 300–1000 h and more than 1000 h, while it decreased the risk of tumors in most subgroup meta-analyses of the INTERPHONE studies.
In sum, the updated comprehensive meta-analysis of case-control studies found significant evidence linking cellular phone use to increased tumor risk, especially among cell phone users with cumulative cell phone use of 1000 or more hours in their lifetime (which corresponds to about 17 min per day over 10 years), and especially among studies that employed high quality methods. Further quality prospective studies providing higher level of evidence than case-control studies are warranted to confirm our findings.
This open access paper and supplemental material can be downloaded at http://bit.ly/cellphonetumor.
Press Release Link from Electromagnetic Radiation Safety
This information is from Dr. Joel Moskowitz
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